The term Nano CBD refers to a form of CBD where the cannabidiol molecule is reduced in a laboratory process to over one-millionth of its original size. Nanotechnology is the science used to reduce the molecular size of CBD, food supplements, and medicines so that they can be more easily absorbed and readily utilized by the body.
The reason, relevance, and objective of utilizing nanotechnology in the formulation of nano CBD Products are to improve bioavailability and subsequent bioactivity (effectiveness). This is achieved when the CBD (or nanomedicine) is absorbed, activated, and utilized before it has a chance to be metabolized by the liver, diluted, and/or lost in the digestive process. For example, nanotechnology is extremely advantageous from a biological and biochemical standpoint when interaction with the liver is not desired.
At increasing levels of intensity, consumers are asking if nano CBD is more effective, and perhaps more economical than traditional forms of CBD?
Over the last 4 years, I have personally observed hundreds of patients who have contacted me at Cannabis Animus seeking pain and anxiety relief as well as better sleep with nano CBD.
With this in mind, I’d like to share some of my understanding from consulting with all of these patients providing guidance typically during their initial therapy period using CBD.
The following information is supported by my own data collected from thousands of our members and customers, as well as research ranging from National Institute of Health's clinical abstracts and their National Center for Biotechnology Information, U.S. National Library of Medicine, to the most cutting-edge clinical research on all things Cannabis from the Multi-Disciplinary Center for Cannabinoid Research at the Hebrew University of Jerusalem in Israel.
My name is Ted Mortenson. I am the author and publisher of Cannabis Animus.
The effects of nano CBD gained relevance to my health and medical condition in 2014 when I was seeking a high-quality CBD product to help me through my next hip surgery (2nd leg this time). Clearly, I was dealing with advanced osteoporosis.
As a Registered Medical Sales Representative (#89372013) with hands-on experience training ophthalmic surgeons (glaucoma specialists) on the Trabectome microsurgical technique (video link) and collateral equipment that I sold to hospitals and surgical centers, I had already gleaned some insight into the use of Cannabis for reducing inter-optic pressure for glaucoma patients. However, it was my ultra-hyper-sensitivity to opioid medications that was my main motivation for first experiencing the potential of CBD therapy for myself.
The results were so astounding from using CBD Living Water as my sole pain medication following my hip replacement surgery that I literally began evangelizing the benefits of nano CBD to everyone that was interested… and even some that weren’t.
Most people with whom I spoke back then didn’t even know what CBD was including physicians and surgeons. When I used the formal name, cannabidiol, many would develop a blank stare... even wince in reaction to the word even when I shared my experience with them using no prescription medication after leaving the hospital. My surgeon was nonetheless fascinated with the speed of my recovery.
Fast forward to 2021, I’ve written extensively on the subject of CBD since first publishing Cannabis Animus in 2016. And now I feel it’s time to offer further support for our members and visitors on the subject of “nano” CBD and elaborate on why it has become so well-accepted and appreciated by patients worldwide.
I’ll be covering the following subjects:
What is CBD?
How does it work? The Endocannabinoid System
What is “nano” CBD, and what’s the difference?
How does Nanotechnology fit in?
Does nano CBD work better?
Benefits of nano CBD
Nano CBD Products
What is CBD?
CBD is an abbreviation for “cannabidiol” which is one of over 100 phytocannabinoids found in all 3 main species of the genus Cannabis (plant family Cannabaceae). Phytocannabinoids are molecules produced by the plant’s glandular organs called trichomes. These trichomes are what produce the sticky resins (containing the cannabinoids and terpenes) that largely protect the female plant's flowers from natural predation and reflect the Sun’s intensity.
The natural resins produced by these trichomes are also rich in “terpenes” (and terpenoids) which are not only the sources of the plant's natural aromas that we all enjoy like limonene (citrus fruits), pinene (pine conifers), and linalool (rose/lavender/jasmine), but more valuable medicinally as natural, biochemical agents that appear to work synergistically with the cannabinoids in the resins produced by these trichomes.
The result of this synergy is an example of what is referred to as an “Entourage Effect” in the context of seeking the most effective, non-prescription Cannabis therapies utilizing as much as desirable. It is these plant cannabinoids and terpenes which appear to improve patient results when they are included together in a Full Spectrum CBD product.
Types Of Cannabinoids
Cannabinoids are classified into sub-types:
Cannabigerol Monoethyl Ether (CBGM)
Tetrahydrocannabinolic acid (THCA)
From a botanical standpoint and growing naturally for over millions of years, these 3 species have been scientifically (taxonomy) acknowledged as Cannabis indica which is most indigenous to Asia, Cannabis sativa found throughout North and South America, and finally, Cannabis ruderalis which is commonly known as “hemp” evidencing prodigious growth and use throughout the world as long as recorded history shows by Sumerian scribes on clay tablets dating as far back as 3200 BC.
Today, CBD is the main ingredient for the most commercially demanded nutraceuticals sought throughout the world by consumers. 2020 CBD sales in the U.S. were about $1.2 Billion and estimated to grow to over $2 Billion by the end of 202.
How Does It Work?
There are interesting developments in this area of discovery worthy of sharing. Although scientists agree on the existence and interactivity of our body’s Endocannabinoid System (ECS) with our immune system, endocrine system (hormones), nervous system, and other main body systems, research is now questioning whether CBD directly influences CB1 and CB2 receptors located throughout the body, or stimulates the body’s endocannabinoids that are naturally produced… or all the above.
This discovery was the biological nexus that consequently lead to today’s common use and acceptance of CBD as a more healthful pain and anxiety relief agent, as well as treating symptoms from neuropathic diseases, collateral medical conditions, and ever increasing symptomologies identified from unhealthy dietary habits and more sedentary lifestyles.
In fact, a new diagnosis has been identified by medical science called Endocannabinoid Deficiency Syndrome (EDS) and is being shared more within the medical community.
EDS is a medical condition that most all patients seeking effective CBD products and therapy are experiencing. In fact, it can be argued that chronic medical conditions and disease cause EDS due to the havoc inherently caused throughout the body.
Our Body’s Endocannabinoid System
In order to better understand how CBD works, you would be best served with a basic understanding of your ECS. In 1992, Dr. Ralph Mechoulam’s associate Dr. Lumir Hanus at the Hebrew University in Jerusalem in collaboration with an American scientist, Dr. William Devane, identified the first endocannabinoid (meaning: cannabinoids created within our own body) called anandamide (AES). Subsequently, Dr. Mechoulam’s research in Cannabis plant anatomy and biochemistry connected the relationship between naturally occurring CBD in Cannabis to its bioactivity within our own endocannabinoid system.
By the early 21st century, Dr. Mechoulam and his colleagues were able to discover a new “system” of receptor cells as the previously referenced as CB1 and CB2 receptor sites and cells located throughout the body that proved to interact with cannabidiol (CBD) and the rest of the cannabinoid family.
It is now understood that CBD is an endocannabinoid ‘modulator’ that has the effect of countering imbalances within the body’s array of many interrelated ‘systems’.
CBD and its fellow cannabinoids and terpenoids (terpenes) help the body naturally return to a condition of homeostasis (balance). Consumer trends are clearly moving away from masking symptoms with “pain killing” and “anti-depressant” drugs including their unwanted and often unhealthy side-effects.
How Does Nanotechnology Fit In?
Nano technology has to do with manipulating all kinds of things at the supramolecular level. This not only includes natural substances like CBD, but it also involves efforts to create cutting-edge physical devices, more effective pharmaceutical drug delivery methods, common personal electronics, and hopefully, much more renewable and intrinsic energy discoveries that will transform human potential.
Whether or not you are aware, CBD and nanotechnology has already become a big part of our lives and our futures. Nanomaterials are currently used in over 2,000 consumer products from communications, coatings, and transportation to textiles, healthcare, and food safety. In the manufacturing and scientific environments it has become ubiquitous and a subject of intense focus.
Nanomedicine is one of the main focuses of nanotechnological research developing and providing new methods of diagnosing, treating, and preventing disease. Nano materials are now destroying cancer cells in clinical trials which are leading to alternatives to traditional cancer therapy. They are slowing the advancement of atherosclerosis (hardening of the arteries) and the plague of heart disease in America.
These nanomaterials and substances are efficient and apparently well tolerated by the body such as nanotubes which are currently used to repair damaged tissue. Nanoadjuvants are immunomodulatory agents that deliver vaccine antigens more effectively.
The “nano-knife” is a virtually non-invasive, microsurgical device and procedure that destroys cancer cells using high-voltage electricity.
Nanoscience studies the structure of things on an ultra-small level and attempts to understand how the change in size affects the usual properties of the substance or device. Nanotechnology is the study of how to design and implement systems at the nanoscale.
Nanotechnology and COVID 19 Vaccines
Relying on RNA Nanotechnology, a number of COVID 19 vaccines have produced the results we needed in record time (regulatory barrier removals notwithstanding).
Protein and Lipid nanoparticles are "enabling some of the most advanced technologies being used in vaccines and drugs."
According to Dr. Daniel Anderson, professor of chemical engineering at the Massachusetts Institute of Technology, “In my mind, one of the heroes in this story is the RNA nanoparticle... because siRNA led to mRNA vaccines." In the latest StatReport on "Nanotechnology in Medicine", the authors examine different kinds of nanomaterials that are being developed for medical applications.
Although the cost of this report is $500, it may be helpful and worth the investment for people considering CBD manufacturing and/or in-channel CBD product sales. They share how they work, and the treatments for which they are being used.
The Nano Scale – How Small is Nano Small?
The human eye has the ability to focus down to a scale of 1 centimeter to 1 millimeter. When we look through a typical high-school lab microscope we are looking at a scale of micrometers (one-thousandth of a millimeter). For example, viruses and bacteria are measured in micrometers, and a typical silicon chip is usually around 1 micrometer thick.
At the nanoscale, we go much smaller yet. Here’s a few examples to give you a better sense for the size of very small things at the nano level (in nanometers).
Hydrogen Atoms… 10 atoms side-by-side = 1 nm
DNA Chain… 2.5 nm
Traditional CBD Isolate Crystal… 4,000 nm
Red Blood Cells… 7,000 nm
Human Hair… 50,000 to 100,000 nm
Sheet of copy paper… 75,000 nm
Consider this… If everyone living on Earth today measured 1 nanometer (nm), we could all fit into a space smaller than half a bar of soap.
It’s no surprise that nanoscience has embraced the subject of CBD therapy and healthcare throughout the world. Still, you may wonder, what’s in it for me?
What Is “Nano” CBD?
... and What's The Difference?
Over the last few decades, more scientists have become able to take natural substances (and physical objects) and reduce them to nano-sized equivalents that are so small that they can be more readily and easily absorbed by the body. As Dr. Anubhav Pratap Singh, PhD at the University of British Columbia describes, “… as we reduce the particles to a few hundred nanometers, some properties of the particles are completely different than the old particles… they can pass through gaps that they were unable to before. So we try to take advantage of this in different forms (like CBD).”
One of the most important and relevant questions I’m asked by our members and customers is “Where does nano CBD come from?
It’s made from many forms of traditional hemp oil, but more recently, hybrid Cannabis strain extracts. These constantly evolving strains and hybrids involve the botanical sciences at work behind the scenes.
These developments are largely what is driving the potential for increased profits from greater yields of CBD from each pound of bulk (raw) plant material harvested. But these are observations at the traditionally ‘organic’ level.
Simply stated, the purpose of nano-sizing the organic CBD molecule to over one-millionth of its original size is along the lines of the following results and benefits:
Increase the speed of delivery
Increase subsequent bioactivity
Increase overall effectiveness
Reduce cost (and/or increase profit)
One of the biggest advantages achieved with nano CBD is the ability to make it ‘almost’ water-soluble by a process commonly referred to as “nano-emulsification”. It’s a way of suspending these incredibly tiny, nano CBD molecules to water clusters that keep the CBD in solution and not sticking to the walls of its container or sinking to the bottom.
This nano-sizing process is constantly being examined, improved, and is currently demonstrated in rapidly growing numbers of new CBD product brands. These contain nano-enhanced hemp oil formulas that are infused into beverages, sublingual oils, vape, and more solid product forms referred to as edibles.
When you consider that CBD consumed in the form of a beverage goes directly to the stomach and then throughout the digestive and filtering organs, nano-sized CBD becomes even more relevant when it is in an edible product, gel cap, or capsule form.
This is because nano-sized CBD is not lost to the digestive process... at least not as much loss of bioavailability as CBD in its more traditionally extracted forms. It is so small that it gets into the bloodstream before it even reaches the liver which is where traditional hemp oil extract is metabolized.
It says "nano" CBD on the label
It is my intention to advise that you not automatically react positively to a CBD product labeled as “nano”. The facts are that many journalists and reporters have conducted random tests on hundreds of CBD products and have subsequently exposed the probability that the majority of products on the market contain less than advertised amounts of CBD and may contain no CBD at all.
Marketing practices in the CBD space are therefore questionable and, as yet, federal regulations have not been fully worked out. So, always buy from a well-acknowledged brand that has stood the test of time or provides the independent 3rd Party Lab test results and related data that smart consumers require.
Common sense will tell you to try nano CBD products that other medical patients use and are willing to recommend.
Remember to never buy any CBD product in any form that does not include a QR Code on the label that provides you instant 3rd party, certified, lab test results.
You can quickly scan with your smartphone/device’s camera and immediately capture the 3rd Party Test Evaluation showing the CBD values as well as the presence of any toxins, heavy metals, or pesticides.
AND, if your selected CBD brand customer service person can't provide you with a report on the size of the nano CBD particulate... then don't buy it for heaven's sake! You do want to know what’s in the container – don’t you?
Does Nano CBD Work Better?
The growth and focus on Nanomedicine in the last decade has provided fertile field for growth in product development from plant-based nutrients used in “vitamin supplements” and other natural, non-addictive alternatives to drugs and Big Pharma’s distribution strategies.
If you ask a patient who has used a traditional CBD hemp oil product and subsequently compared it to a well-established, high-quality, 3rd Party Tested, QR coded, and documented nano CBD product, they’ll likely tell you that they continue to use it and prefer a nano CBD product.
So, let me turn it around and ask you a simple question. If customers do not re-order the traditional CBD hemp oil products or cheap CBD isolate-based products, but instead consistently re-order nano CBD products…
What would that tell you if you were interested in determining the best product and the best possible results if taken properly and in the correct dose.
Full disclosure, I've been personally testing and publishing reviews on CBD products for over 4 years now, and I have offered many brands of CBD products for sale within that time.
What I've found is that traditionally-formulated hemp oil products or CBD isolate formulations are seldom re-ordered by customers who purchased them... even when I performed the due diligence, research, and recommendation.
So, what happened?
It’s quite revealing from my perspective. As opposed to most other authors on the subject, I have many years of experience working directly with hundreds of our members and patients at Cannabis Animus for their specific conditions and symptoms. This unique experience with so many patients suggests that you compare for yourself as well.
Nano CBD products are no more expensive at Cannabis Animus than traditional hemp oil equivalents anywhere else.
According to the National Institute of Health, one of their clinical studies in 2018 of an orally-administered nano CBD formulation showed an increase in the bioactivity of 131% from pharmacokinetic analyses of blood samples.
Patient results have only improved since then, and advancements in nanotechnology and nanoscience by 2020 has become even more significant. The study’s researchers concluded that nano CBD absorbed through the buccal mucosa tissues in the mouth and/or any “first pass” digestive or otherwise metabolized after ingestion is “a safe and effective delivery platform for both CBD and THC."
Benefits of Nano CBD
Nervous system – Neuropathic pain & anxiety relief
Immune System – Biologic and toxic environmental considerations
Blood Chemistry – Diabetes, hypertension, and reversible medical conditions
Increased Bioavailability of CBD – Avoids digestive system loss
Increased Bioactivity of CBD – Full dose effectiveness and economy
Faster Acting – Nano sized CBD enters the body and blood stream quickly
Reduces Inflammation – Naturally, without unnecessary side effects from NSAIDs
Avoids Conflicts with prescription medications metabolized in the liver
Easily Absorbable into the layers of skin and its blood supply
*The above list should be well understood by your physicians by now, so I highly advise that you share this information with them.
Nano CBD Products
Another advantage that comes with nano CBD products is that you have a much more broad range of product types from which to choose. As mentioned earlier, nano CBD opened up the entire world of beverages with nano CBD infusion. Everything from water to soft drinks, beer, and energy shots. More and more brands are adding nano CBD to their list of ingredients.
Edible products ranging from candy treats like CBD gummies and chocolate confections to nutritional products, athletic performance, sleep aids, cold symptom lozenges, and even cooking and baking ingredients like cannabutter is now common and easy to make in your own kitchen.
Topical CBD products like transdermal patches, lotions, salves, roll-on emulsions, and bath products are some of the most widely used new product types. These are also recommended to be used in conjunction with orally administered CBD in larger doses.
Nano CBD suppositories (anal/vaginal) and topical patches are recommended by physicians when interaction with the liver is best avoided. This can be due to any number of reasons including the discovery that CBD can have the effect of rendering some prescription medications less effective when metabolized together in the liver. Always take CBD on an empty stomach for the best results.
Patients extoll the relief they get from nano CBD more than those suffering from mental and emotional conditions such as PTSD, severe anxiety, and depression. CBD vape products (inhaling CBD vapor) are widely available in the form of disposable vape pens, or more concentrated forms like shatter and crystalline isolate via dab rigs and myriad forms of vaporizers on the market. Quality vape products do not contain Vitamin E acetate, vegetable glycerin (VG), or propylene glycol (PG). Products containing these additives should be avoided.
Traditional products in the form of gel capsules or sublingual tincture oil remain the most popular forms of nano CBD products.
Many biochemists, physicians, and health professionals have told me that they recommend their patients compare these two basic forms of CBD. That being traditional CBD hemp oil products compared to nano CBD products. The data is expanding rapidly, and it’s only logical that consumers do their own due diligence as they would any other ingestible, heallth product.
As Dr. Singh affirms regarding his confidence in nano CBD and nanoscience, “We’re starting to see some very good quality papers coming in already about Cannabis and nanotechnology and its impact on health.”
He continues... “Moving into 2020, I think most of the Cannabis products in the market will be produced in this way.”
My eBook is available for you to download for free and provides further information on the subject called “Traditional CBD Hemp Oil vs. Nano CBD”
If you have any feedback or testimonials, please don’t leave without sharing your comments below… Our members and visitors want to hear from you!
Check out my articles & reviews on nano CBD and products:
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